DLCN score

  • Family history

    • 1.
      Is anyone among the patient's parent, sibling, or child (first degree relative) with known premature* coronary and/or vascular disease?
      Yes No
    • 2.
      Is anyone among the patient's parent, sibling, or child (first degree relative) with known LDL-cholesterol above the 95th percentile for age and gender (appendix 1, 2 & 3)?
      Yes No
    • 3.
      Is anyone among the patient's parent, sibling, or child (first degree relative) with tendinous xanthomata and/or arcus cornealis?
      Yes No
    • 4.
      If the patient is aged <18 years, is his/her LDL-cholesterol above the 95th percentile for age and gender (appendix 1)?
      Yes No

  • Clinical history

    • 5.
      Does the patient have premature* coronary artery disease (CAD)?
      Yes No
    • 6.
      Does the patient have premature* cerebral or peripheral vascular disease?
      Yes No

  • Physical examination

  • LDL-Cholesterol level

    • The patient's untreated LDL cholesterol level is

  • DNA Analysis

    • 9.
      Does the patient have a functional mutation in the LDLR, apo B or PCSK9 gene?
      Yes No

DLCN Score

-

Submit to see result

FOOTNOTES

*premature means men aged <55 years, women aged <60 years

REFERENCES:
  1. Nordestgaard BG, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J. 2013; 34:3478a-3490a.
  2. Ibrahim S, et al. Advances, gaps and opportunities in the detection of familial hypercholesterolemia: overview of current and future screening and detection methods. Curr Opin Lipidol. 2020;31(6):347-355.
  3. Haralambos K, et al. Diagnostic scoring for familial hypercholesterolaemia in practice. Curr Opin Lipidol. 2016;27(4):367-74.
  4. Brett T et al. Familial hypercholesterolaemia: challenges in primary care. Medicine Today. 2015;16(8):20-26.
  5. Balder JW, et al. Lipid and lipoprotein reference values from 133,450 Dutch Lifelines participants: Age- and gender-specific baseline lipid values and percentiles. J Clin Lipidol. 2017;11(4):1055-1064.e6.
  6. Balder JW, et al. Pediatric lipid reference values in the general population: The Dutch lifelines cohort study. J Clin Lipidol. 2018;12(5):1208-1216.